An instrument that measures the degree of dissolution of medicines. The drug dissolution apparatus is an effective alternative method for in vitro research and evaluation of drug bioavailability in vivo, and it is also an important means to ensure and measure whether the production process and quality of solid oral preparations are reasonable and stable. It replaces the past disintegration time limit inspection with scientific and advanced measurement methods, thereby improving the scientific nature of drug quality control methods and ensuring the clinical efficacy of drugs.
Influencing factors:
1. The degree of medium degassing, liquid temperature, instrument vibration, stirring speed, sampling point location, filtering speed, drug position in the cup or basket, etc.
2. Factors of the drug itself, such as solubility, surface area of the drug, structure and crystal form of the drug.
3. Factors related to formulations, such as dosage form, prescription, excipients, technology, drug interactions, surfactants, particle size and total area after the disintegration of the formulation or the release of the main drug.
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