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Whether the pharmaceutical dissolution tester is used correctly is directly related to the dissolution effect of the dissolution test, and improper operation can easily cause damage to the instrument. So, what should be paid attention to when using the dissolution tester?
I. Preparations for the dissolution test
1. Install and adjust the rotation rod of medical dissolution tester
2. Mode switch
3. Inject the solvent
II. Details to be paid attention during the dissolution test
1. When the temperature of the solvent in the dissolution vessel is stable at the specified value, the dissolution test can be started.
2. Put the test product into the solvent and cover the lid. For the basket method, raise the machine head, place the test product in the mesh basket and install it, then lower the machine head and cover the lid.
3. Start the rotary lever to run.
III. Things to be paid attention to when the sampling time is up
1. Use a syringe with a corresponding curved needle and a needle pad, insert through the sampling hole on the lid into the cup to extract the sample.
2. The curved needle and needle pad are designed so that the end of the needle is at the sampling point specified in the Pharmacopoeia.
IV. After dissolution experiment
At the end of the dissolution experiment, raise the head of laboratory dissolution tester, turn off the rotating rod and the temperature control state, and turn off the total power switch. Unscrew the clutch, remove the rotating rod, wash, dry, and store them in the accessory box. Other accessories should also be kept clean and properly stored. Take out the dissolution vessel, pour out the residual liquid, clean it, and store it for later use.