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The pharmaceutical dissolution tester is an effective alternative method for studying and evaluating the bioavailability of medicine in vivo in vitro. It is also an important means to ensure and measure whether the production process and quality of solid oral preparations are reasonable and stable.
The scientific and advanced measurement method of pharmaceutical dissolution apparatus have replaced the previous disintegration time limit inspection, thereby improving the scientific nature of medicine quality control methods and ensuring the clinical efficacy of medicine. Usually they can be divided into:
1. Semi-automatic dissolution tester and fully automatic dissolution tester
2. Single-cup dissolution tester, three-cup dissolution tester, six-cup dissolution tester, eight-cup dissolution tester, twelve-cup dissolution tester
Correct operation of pharmic dissolution tester:
1. During the measurement process, the water level must be at least 2cm higher than the water outlet at the right end of the water tank, otherwise do not turn on the machine.
2. When the machine is turned on for the first time, the water level should drop by 1cm. If there are bubbles coming out of the water nozzle, it means that there is water in the heating box, otherwise do not turn on it.
3. If there is no digital display after turning on the machine, and the power indicator light is not on, check whether the fuse is burned out and whether the power supply voltage is normal.
4. If the temperature digital display jumps randomly after turning on the machine, check whether the connection between the turbidity measuring line plug and the sensor socket is good.
5. Do not insert the temperature sensor into the dissolution cup solvent to avoid corrosion of the sensor thermistor.